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[ESC2009]ACCOMPLISH研究的应用及单片复方制剂(SPC)在高血压治疗中的地位--Weber教授专访

作者:国际循环网   日期:2009/9/3 18:26:00

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ACCOMPLISH研究是第一个将固定剂量复合制剂(SPC)RAAS/CCB同RAAS/利尿剂用于高血压或高心血管事件风险的患者效果比较的试验,您认为这个研究是否会推动固定复方制剂(single-pill combination,SPC)在临床高血压治疗中的广泛应用呢?您认为ACCOMPLISH研究对JNC8及ESC/ESH高血压指南对于SPC的临床应用将会有何影响?请您谈谈SPC在高血压治疗中的地位。


International Circulation:  Is SPC a reasonable choice in diabetics with hypertension in antihypertensive therapy?

国际循环:对合并糖尿病的高血压患者,SPC是否是合理的降压选择?

Michael Weber:  We found that in a very large number of diabetic patients, in fact over half the patients in ACCOMPLISH did have type II diabetes, that these approaches to therapy were extremely efficacious.  These patients finished with very well reduced blood pressure.  I was gratified that both the amlodipine/RAAS blocker, and the hydrochlorothiazide/RAAS blocker were both very effective in our diabetic patients.  So, yes, for people with diabetes, people with different ethnic backgrounds, as far as we could see it didn’t matter if people were Caucasian, if they were black, if they were of Asian origin, everyone seemed to get very very effective blood pressure reduction.

Michael Weber教授:事实上ACCOMPLISH中超过半数合并2型糖尿病,这种疗法对大多数糖尿病患者非常有效。研究结束时,这些患者的血压得到很好控制。氨氯地平/RAAS阻断剂与双氢克尿噻/RAAS阻断剂都可以有效降低糖尿病患者的血压。因此,无论对高加索人、黑人还是亚洲人糖尿病患者,都能良好降压。

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ACCOMPLISH单片复方制剂倍博特阿利吉仑

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